Detalhe da pesquisa
1.
From structure to clinic: Design of a muscarinic M1 receptor agonist with potential to treatment of Alzheimer's disease.
Cell
; 184(24): 5886-5901.e22, 2021 11 24.
Artigo
Inglês
| MEDLINE | ID: mdl-34822784
2.
Crystal structure of the GLP-1 receptor bound to a peptide agonist.
Nature
; 546(7657): 254-258, 2017 06 08.
Artigo
Inglês
| MEDLINE | ID: mdl-28562585
3.
Corrigendum: Crystal structure of the GLP-1 receptor bound to a peptide agonist.
Nature
; 548(7665): 122, 2017 08 03.
Artigo
Inglês
| MEDLINE | ID: mdl-28700581
4.
Extra-helical binding site of a glucagon receptor antagonist.
Nature
; 533(7602): 274-7, 2016 05 12.
Artigo
Inglês
| MEDLINE | ID: mdl-27111510
5.
Identification of a novel allosteric GLP-1R antagonist HTL26119 using structure- based drug design.
Bioorg Med Chem Lett
; 29(20): 126611, 2019 10 15.
Artigo
Inglês
| MEDLINE | ID: mdl-31447084
6.
Glucagon-Like Peptide-1 and Its Class B G Protein-Coupled Receptors: A Long March to Therapeutic Successes.
Pharmacol Rev
; 68(4): 954-1013, 2016 10.
Artigo
Inglês
| MEDLINE | ID: mdl-27630114
7.
A novel somatostatin receptor ligand for human ACTH - and GH -secreting pituitary adenomas.
Eur J Endocrinol
; 190(1): K8-K16, 2024 Jan 03.
Artigo
Inglês
| MEDLINE | ID: mdl-38123488
8.
Regional characterisation of TRPV1 and TRPA1 signalling in the mouse colon mucosa.
Eur J Pharmacol
; 954: 175897, 2023 Sep 05.
Artigo
Inglês
| MEDLINE | ID: mdl-37394028
9.
Expanding the apelin receptor pharmacological toolbox using novel fluorescent ligands.
Front Endocrinol (Lausanne)
; 14: 1139121, 2023.
Artigo
Inglês
| MEDLINE | ID: mdl-36967803
10.
Differential signaling by splice variants of the human free fatty acid receptor GPR120.
Mol Pharmacol
; 81(5): 631-42, 2012 May.
Artigo
Inglês
| MEDLINE | ID: mdl-22282525
11.
A phase 1b/2a multicenter study of the safety and preliminary pharmacodynamic effects of selective muscarinic M1 receptor agonist HTL0018318 in patients with mild-to-moderate Alzheimer's disease.
Alzheimers Dement (N Y)
; 8(1): e12273, 2022.
Artigo
Inglês
| MEDLINE | ID: mdl-35229025
12.
In vitro metabolism of synthetic Elabela/Toddler (ELA-32) peptide in human plasma and kidney homogenates analyzed with mass spectrometry and validation of endogenous peptide quantification in tissues by ELISA.
Peptides
; 145: 170642, 2021 11.
Artigo
Inglês
| MEDLINE | ID: mdl-34455010
13.
Acetylcholine prioritises direct synaptic inputs from entorhinal cortex to CA1 by differential modulation of feedforward inhibitory circuits.
Nat Commun
; 12(1): 5475, 2021 09 16.
Artigo
Inglês
| MEDLINE | ID: mdl-34531380
14.
Short Chain Fatty Acids Enhance Expression and Activity of the Umami Taste Receptor in Enteroendocrine Cells via a Gαi/o Pathway.
Front Nutr
; 7: 568991, 2020.
Artigo
Inglês
| MEDLINE | ID: mdl-33195366
15.
Advances in therapeutic peptides targeting G protein-coupled receptors.
Nat Rev Drug Discov
; 19(6): 389-413, 2020 06.
Artigo
Inglês
| MEDLINE | ID: mdl-32494050
16.
Structure-Based Drug Discovery of N-((R)-3-(7-Methyl-1H-indazol-5-yl)-1-oxo-1-(((S)-1-oxo-3-(piperidin-4-yl)-1-(4-(pyridin-4-yl)piperazin-1-yl)propan-2-yl)amino)propan-2-yl)-2'-oxo-1',2'-dihydrospiro[piperidine-4,4'-pyrido[2,3-d][1,3]oxazine]-1-carboxamide (HTL22562): A Calcitonin Gene-Related Peptide Receptor Antagonist for Acute Treatment of Migraine.
J Med Chem
; 63(14): 7906-7920, 2020 07 23.
Artigo
Inglês
| MEDLINE | ID: mdl-32558564
17.
Discovery of small molecule human C5a receptor antagonists.
Bioorg Med Chem Lett
; 19(4): 1143-7, 2009 Feb 15.
Artigo
Inglês
| MEDLINE | ID: mdl-19171482
18.
Cholinergic muscarinic M1 and M4 receptors as therapeutic targets for cognitive, behavioural, and psychological symptoms in psychiatric and neurological disorders.
Drug Discov Today
; 24(12): 2307-2314, 2019 12.
Artigo
Inglês
| MEDLINE | ID: mdl-31499186
19.
A monoclonal antibody raised against a thermo-stabilised ß1-adrenoceptor interacts with extracellular loop 2 and acts as a negative allosteric modulator of a sub-set of ß1-adrenoceptors expressed in stable cell lines.
Biochem Pharmacol
; 147: 38-54, 2018 01.
Artigo
Inglês
| MEDLINE | ID: mdl-29102678
20.
Indazole-6-phenylcyclopropylcarboxylic Acids as Selective GPR120 Agonists with in Vivo Efficacy.
J Med Chem
; 60(7): 3187-3197, 2017 04 13.
Artigo
Inglês
| MEDLINE | ID: mdl-28374589